Three other neuronal MAGUKs, PSD-93, synapse-associated protein (SAP)-97, and SAP-102, are also expressed in neurons throughout the brain. The prototypical PDZ protein, PSD-95, is a membrane-associated guanylate kinase (MAGUK) that contains three PDZ domains and associates with NMDA receptors at the synapse. PDZ domain proteins in metazoans function in diverse roles, and in conjunction with PDZ domain-binding proteins form macromolecular complexes for signaling at synapses and cell junctions. PDZ domain-containing proteins, consistent with the idea that both receptors may cross-talk at synapses. Among others, a subset of PDZ domain‐containing proteins (PDZ proteins) bind to the channel and play a critical role in regulating the channel function (Calin‐Jageman & Lee, 2008). Binding of synGAP to PDZ domains of PSD-95 and its role in Intellectual Disability and Autism Spectrum Disorders caused by synGAP haploinsufficiency. PDZ proteins are key organizers at synapses (Kim & Sheng, 2004; Sheng, 2001). The C terminus of GluR-A bound to the PDZ domains of SAP97, but not to those of three related MAGUKs, PSD-93, PSD-95, and SAP102. This interaction of the ErbB-4 receptor tyrosine kinase with MAGUKs at neuronal synapses increases the repertoire of signaling proteins present at the PSD. Unexpectedly, mutation Experiments with single PDZ domains indicated that the strongest contribution was by the second PDZ domain. The first PDZ-domain-containing protein to be identified at vertebrate CNS synapses was SAP90/PSD-9514, 15.Subsequently, three additional isoforms, SAP97/hDlg, SAP102 and Chapsyn110/ PSD93, were characterized 2.Members of this family of synapse-associated proteins (SAPs), although localized primarily at the PSD of type 1 excitatory glutamatergic synapses, have also been found … A protein motif called a PDZ domain is important in the targeting of a variety of membrane proteins to cell–cell junctions including synapses 8–10. Kim E, Sheng M. PDZ domain proteins of synapses. Nat Rev Neurosci 5: 771-781 The primary antibodies used were: anti-PSD-95 View protein in PROSITE PS00478, LIM_DOMAIN_1, 2 hits PS50023, LIM_DOMAIN_2, 3 hits PS50106, PDZ p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. Materials and Methods Antibodies. However, there are hundreds of proteins predicted to possess PDZ domain-binding … PDZ domains can therefore be used in combination to bind an array of target proteins or to oligomerize into branched networks. These domains specifically recognize short C-terminal peptide motifs, but can also recognize internal sequences that structurally mimic a terminus. GluR-A and synapse-associated protein 97 (SAP97). PDZ domains are protein-protein recognition modules that play a central role in organizing diverse cell signaling assemblies. Proteins that regulate glutamate receptor clustering at synapses include scaffolding molecules that contain PDZ (postsynaptic density-95/Discs large/zona occludens–1) domains and postsynaptic adaptor proteins (3, 4), as well as proteins that regulate endosomal trafficking . Bioinformatics approaches using the SMART tool indicate there are only a modest number of Arabidopsis PDZ proteins.
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